| In den folgenden Publikationen waren Mitarbeiter von Epigenomics Autoren oder Ko-Autoren:
Wissenschaftliche Artikel:
DARMKREBS
- Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer
Clinical Chemistry 55:7/ 1337-1346
Theo deVos, Reimo Tetzner, Fabian Model, Gunter Weiss, Matthias Schuster, Jürgen Distler, Kathryn V. Steiger, Robert Grützmann, Christian Pilarsky, Jens K. Habermann, Phillip R. Fleschner, Benton M. Oubre, Robert Day, Andrew Sledziewski, and Catherine Lofton-Day
- Sensitive Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay
PLoS One 3(11): e3759. doi:10.1371/journal.pone.0003759
Grützmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, et al.
- Distinct TPEF/HPP1 gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis
Dig Liver Dis. 2008 Dec;40(12):920-6.
Ivanauskas A, Hoffmann J, Jonaitis LV, Markelis R, Juozaityte E, Kupcinskas L, Lofton-Day C, Röcken C, Malfertheiner P.
- DNA-Methylation Biomarkers for Blood-Based Colorectal Cancer Screening.
Clin. Chem., Dec 2007.
Lofton-Day C, Model F, DeVos T, Tetzner R, Distler J, Schuster M, Song X, Lesche R, Liebenberg V, Ebert M, Molnar B, Grutzmann R, Pilarsky C, and Sledziewski A.
- Identification and validation of colorectal neoplasia-specific methylation markers for accurate classification of disease.
Mol Cancer Res. 2007 Feb;5(2):153-63.
Model, F. et al.
- Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas.
Gastroenterology. 2006 Nov;131(5):1418-30.
Ebert M.P. et al.
- Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia.
Clin Gastroenterol Hepatol. 2006 Feb;4(2):212-8.
Osborn, N.K. et al.
- Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers.
Neoplasia. 2005 Aug;7(8):771-8.
Ebert, M.P. et al.
- Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis.
Carcinogenesis. 2005 Jan;26(1):37-43.
Chen, J. et al.
- DNA methylation markers in patients with gastrointestinal cancers. Current understanding, potential applications for disease management and development of diagnostic tools.
Dig Dis. 2003;21(4):299-308.
Lofton-Day, C. and R. Lesche
LUNGENKREBS
- Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer.
Int J Biochem Cell Biol. 2007 Dec 7;
Cortese R, Hartmann O, Berlin K, Eckhardt F.
- Methylation discriminators in NSCLC identified by a microarray based approach.
Int J Oncol 27: 105-111, 2005. June 13, 2005
J.K. Field, T. Liloglou, S. Warrak, M. Burger, E. Becker, K. Berlin, I. Nimmrich and S. Maier (Liverpool, UK; Berlin, Germany)
PROSTATAKREBS
- DNA methylation biomarkers of prostate cancer: confirmation of candidates and evidence urine is the most sensitive body fluid for non-invasive detection.
Prostate. 2009 Sep 1;69(12):1257-69.
Payne SR, Serth J, Schostak M, Kamradt J, Strauss A, Thelen P, Model F, Day JK, Liebenberg V, Morotti A, Yamamura S, Lograsso J, Sledziewski A, Semjonow A.
- DNA methylation of the PITX2 gene promoter region is a strong independent prognostic marker of biochemical recurrence in patients with prostate cancer after radical prostatectomy.
J Urol. 2009 Apr;181(4):1678-85.
Weiss G, Cottrell S, Distler J, Schatz P, Kristiansen G, Ittmann M, Haefliger C, Lesche R, Hartmann A, Corman J, Wheeler T.
- Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
J Urol. 2007 May;177(5):1753-8.
Cottrell S, Jung K, Kristiansen G, Eltze E, Semjonow A, Ittmann M, Hartmann A, Stamey T, Haefliger C, Weiss G.
Also, all the breast cancer publications that concern the PITX2 biomarker are relevant to prostate cancer since it is our “premier” prostate cancer biomarker at the moment.
BRUSTKREBS
- DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy.
Clin Cancer Res. 2009 Jan 1;15(1):315-23.
Hartmann O, Spyratos F, Harbeck N, Dietrich D, Fassbender A, Schmitt M, Eppenberger-Castori S, Vuaroqueaux V, Lerebours F, Welzel K, Maier S, Plum A, Niemann S, Foekens JA, Lesche R, Martens JW.
- Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.
J Clin Oncol. 2008 Nov 1;26(31):5036-42.
Harbeck N, Nimmrich I, Hartmann A, Ross JS, Cufer T, Grützmann R, Kristiansen G, Paradiso A, Hartmann O, Margossian A, Martens J, Schwope I, Lukas A, Müller V, Milde-Langosch K, Nährig J, Foekens J, Maier S, Schmitt M, Lesche R.
- DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.
Breast Cancer Res Treat. 2008 Oct;111(3):429-37.
Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME, Schwope I, Bolt-de Vries J, Harbeck N, Koenig T, Hartmann O, Kluth A, Dietrich D, Magdolen V, Portengen H, Look MP, Klijn JG, Lesche R, Schmitt M, Maier S, Foekens JA, Martens JW.
- Multiplexed methylation analysis - a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast
Verh Dtsch Ges Pathol. 2007;91:197-207. German.
Dietrich D, Schuster M, Lesche R, Haedicke W, Kristiansen G.
- DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.
Breast Cancer Res Treat. 2007 Oct 28;
Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME, Schwope I, Bolt-de Vries J, Harbeck N, Koenig T, Hartmann O, Kluth A, Dietrich D, Magdolen V, Portengen H, Look MP, Klijn JG, Lesche R, Schmitt M, Maier S, Foekens JA, Martens JW.
- The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study.
Breast Cancer Res Treat. 2007 Sep 13;
Golouh R, Cufer T, Sadikov A, Nussdorfer P, Usher PA, Brünner N, Schmitt M,
Lesche R, Maier S, Timmermans M, Foekens JA, Martens JW.
- DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
Eur J Cancer. 2007 Jul;43(11):1679-86. Epub 2007 Jun 29.
Maier S, Nimmrich I, Koenig T, Eppenberger-Castori S, Bohlmann I, Paradiso A, Spyratos F, Thomssen C, Mueller V, Nährig J, Schittulli F, Kates R, Lesche R, Schwope I, Kluth A, Marx A, Martens JW, Foekens JA, Schmitt M, Harbeck N; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
- DNA methylation markers - an opportunity to further individualize therapy in breast cancer?
Personalized Medicine, November 2005, Vol. 2, No. 4, Pages 339-347
Sabine Maier et al.
- Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.
Cancer Res 2005; 65; (10). May 15, 2005
John W.M. Martens et al.
LEUKÄMIE & LYMPHOMA
- DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas.
Int J Biochem Cell Biol. 2007;39(7-8):1523-38.
Ivascu C, Wasserkort R, Lesche R, Dong J, Stein H, Thiel A, Eckhardt F.
- Differential DNA methylation of gene promoters in small B-cell lymphomas.
Am J Clin Pathol. 2005;124:430-439
Guo J, Burger M, Nimmrich I, Maier S, Becker E, Genc B, Duff D,
Rahmatpanah F, Chitma-Matsiga R, Shi H, Berlin K, Huang Tim H.-M., Caldwell CW
- Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis.
Ann Hematol. 2005 Apr;84(4):236-44. Epub 2004 Nov 6,
Scholz C, Nimmrich I, Burger M, Becker E, Dorken B, Ludwig WD, Maier S.
- The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas
Clin Cancer Res 2003 9: 4034-4042
Hongyu Yang et al.
PHARMAKOGENOMIK, ALLGEMEINES
- DNA methylation: potential for diagnosis, prognosis and therapy-prediction in oncology
Verh Dtsch Ges Pathol. 2006;90:39-45. German.
Haedicke W, Lesche R.
- Comparative DNA methylation analysis in normal and tumour tissues and in cancer cell lines using differential methylation hybridisation.
Int J Biochem Cell Biol. 2007;39(7-8):1539-50.
Lewin J, Plum A, Hildmann T, Rujan T, Eckhardt F, Liebenberg V, Lofton-Day C,
Wasserkort R.
- DNA methylation profiling of human chromosomes 6, 20 and 22.
Nature Genetics (2006): published online 18.00 UK time, 29 October 2006; doi:10.1038/ng1909
Eckhardt et al.
- "Molecular diagnostic applications of DNA methylation technology"
Clinical Laboratory International, October 2005, volume 29 6, pp18-21
Susan Cottrell
- Identifying DNA methylation biomarkers of cancer drug response.
Am J Pharmacogenomics. 2005;5(4):223-32
Maier S, Dahlstroem C, Haefliger C, Plum A, Piepenbrock C
- DNA Methylation Profiling of the Human Major Histocompatibility Complex:
A Pilot Study for the Human Epigenome Project.
PLoS Biol. 2004 Nov 23;2(12):e405.
VK Rakyan et al.
- Future potential of the Human Epigenome Project
Expert Rev Mol Diagn, 2004 Sep;4(5):609-18.
- Molecular diagnostic applications of DNA methylation technology.
Clin Biochem. 2004 Jul;37(7):595-604.Review, PMID: 15234241
Susan Cottrell et al.
- Building the bridge between molecular diagnostics and therapeutics.
Expert Rev Mol Diagn. 2003 Nov;3(6):681-3.
Schweikhardt RG, Piepenbrock C, Sledziewski AZ.
- Epigenomics: Genome-Wide Study of Methylation Phenomena
Curr. Issues Mol. Biol. 4:111-128,
Novik et al. 2002
- Expressed CpG Island Sequence Tag Microarray for Dual Screening of DNA Hypermethylation and Gene Silencing in Cancer Cells
Cancer Research 62, 3214–3220, June 1, 2002
Tim Hui-Ming Huang et al.
- Tumour class prediction and discovery by microarray-based DNA methylation analysis
NAR online, vol 30 n. 5,
Adorjan et al. 2002
- Diabetes: A Candidate Disease for Efficient DNA Methylation Profiling
J. Nutr. 2002 132: 2440S-2443S
Sabine Maier and Alexander Olek, Aug 2002
TECHNOLOGIE
- Quantification of methylated DNA by HeavyMethyl duplex PCR.
Methods Mol Biol. 2009;507:339-46.
Distler J.
- Prevention of PCR cross-contamination by UNG treatment of bisulfite-treated DNA.
Methods Mol Biol. 2009;507:357-70.
Tetzner R.
- Analysis of DNA methylation of multiple genes in microdissected cells from formalin-fixed and paraffin-embedded tissues.
J Histochem Cytochem. 2009 May;57(5):477-89.
Dietrich D, Lesche R, Tetzner R, Krispin M, Dietrich J, Haedicke W, Schuster M, Kristiansen G.
- Control of carry-over contamination for PCR-based DNA methylation quantification using bisulfite treated DNA
Nucleic Acids Research, doi:10.1093/nar/gkl955, Nov 28, 2006
Reimo Tetzner et al.
- Rapid analysis of CpG methylation patterns using RNase T1 cleavage and MALDI-TOF
Nucleic Acids Research, Online-Veröffentlichung am 2. Dezember 2004
Abstract, Full Text
Philipp Schatz, Dimo Dietrich and Matthias Schuster
- Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates.
Bioinformatics Advance Access, 2004, July 9 (online).
Jörn Lewin, Armin O. Schmitt, Péter Adorján, Thomas Hildmann, Christian Piepenbrock
- A real-time PCR assay for DNA-methylation using methylation-specific blockers.
Nucleic Acids Research, 2004, Vol. 32, No. 1 e10
Susan Cottrell et al.
- Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.
Nucleic Acids Res. 2003 May 1;31(9):e50.
Tost J, Schatz P, Schuster M, Berlin K, Gut IG.
- Sensitive detection of DNA methylation.
Ann N Y Acad Sci. 2003 Mar; 983:120-30. Review, PMID: 12724217
Susan Cottrell et al.
- Oligonucleotide-based microarray for DNA methylation analysis: Principles and applications.
J Cell Biochem 2003;88(1):138-43
Shi H, Maier S, Nimmrich I, Yan PS, Caldwell CW, Olek A, Huang TH.
- Statistical process control for large scale microarray experiments
Bioinformatics Vol. 18 no. 90001 2002, Pages S155-S163,
Fabian Model et al.
- Feature selection for DNA-methylation based cancer classification
Bioinformatics vol 17,
Model et al. 2001
Im Folgenden werden einige Reviews aufgelistet, die die besondere Bedeutung der DNA-Methylierung für Krebs beschreiben:
- Epigenetics in cancer., Esteller M., N Engl J Med. 2008 Mar 13;358(11):1148-59.
- DNA methylation markers: a versatile diagnostic tool for routine clinical use., Lesche R, Eckhardt F. Curr Opin Mol Ther. 2007 Jun;9(3):222-30.
- The epigenomics of cancer., Jones PA, Baylin SB. Cell. 2007 Feb 23;128(4):683-92.
- How the genome integrates intrinsic and environmental signals.
Jaenisch, R, Bird A (2003) Nat Get (Suppl) 33: 245-254
- Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
Hannes M Mueller, Martin Widschwendter. Expert Rev. Mol. Diagn. 3(4), 443-458 (2003)
- The power and the promise of DNA methylation markers
PW Laird. Nature Rev. Cancer 3, 253-266 (2003)
- The fundamental role of epigenetic events in cancer
Jones et al. Nature Reviews Genetics, vol. 3 (6) June 2002, pp. 415-428
- Behind the Scenes of Gene Expression
Elizabeth Pennisi, Science Aug 10 2001: 1064-1067
- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
Eric Lander, Rudolf Jaenisch
Nature Genetics, vol 27, January 2001
- Current Topics in Microbiology and Immunology. Vol. 249: DNA Methylation and Cancer edited
P. A. Jones, P. K. Vogt
Springer-Verlag (2000), S. 170ff
- DNA methylation in health and disease
Robertson KD, Wolffe AP
Nature Reviews Genetics. 2000 October, Vol.1:11-19
- DNA methylation: past, present and future directions
Robertson KD, Jones PA.
Carcinogenesis. 2000 Mar;21(3):461-7. PMID: 10688866; UI: 20156136
- DNA methylation
Singal R, Ginder GD.
Blood. 1999 Jun 15;93(12):4059-70. PMID: 10361102; UI: 99290759
- Cancer epigenetics comes of age
Jones PA, Laird PW.
Nat Genet. 1999 Feb;21(2):163-7.PMID: 9988266; UI: 9914076
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