Books:

• DNA Methylation and Cancer Therapy
  Editor: Moshe Szyf
  ISBN: 1-58706-218-6
• Epigenetics in Cancer Prevention: Early Detection and Risk Assessment (Annals of the New York Academy of Sciences, Vol 983)
  Editor: Mukesh Verma
  ISBN 1-57331-431-5
• The Epigenome: Molecular Hide and Seek
  S. Beck (Editor), A. Olek (Editor)
  ISBN: 3527304940

Papers:

• Multiplexed methylation analysis - a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast
  Verh Dtsch Ges Pathol. 2007;91:197-207. German.
  Dietrich D, Schuster M, Lesche R, Haedicke W, Kristiansen G.
• DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients.
  Breast Cancer Res Treat. 2007 Oct 28;
  Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME, Schwope I, Bolt-de Vries J, Harbeck N, Koenig T, Hartmann O, Kluth A, Dietrich D, Magdolen V, Portengen H, Look MP, Klijn JG, Lesche R, Schmitt M, Maier S, Foekens JA, Martens JW.
• The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study.
  Breast Cancer Res Treat. 2007 Sep 13;
  Golouh R, Cufer T, Sadikov A, Nussdorfer P, Usher PA, Brünner N, Schmitt M,
  Lesche R, Maier S, Timmermans M, Foekens JA, Martens JW.
• DNA methylation: potential for diagnosis, prognosis and therapy-prediction in oncology
  Verh Dtsch Ges Pathol. 2006;90:39-45. German.
  Haedicke W, Lesche R.
• DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
  Eur J Cancer. 2007 Jul;43(11):1679-86. Epub 2007 Jun 29.
  Maier S, Nimmrich I, Koenig T, Eppenberger-Castori S, Bohlmann I, Paradiso A, Spyratos F, Thomssen C, Mueller V, Nährig J, Schittulli F, Kates R, Lesche R, Schwope I, Kluth A, Marx A, Martens JW, Foekens JA, Schmitt M, Harbeck N; European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group.
• DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas.
  Int J Biochem Cell Biol. 2007;39(7-8):1523-38.
  Ivascu C, Wasserkort R, Lesche R, Dong J, Stein H, Thiel A, Eckhardt F.
• Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer.
  Int J Biochem Cell Biol. 2007 Dec 7;
  Cortese R, Hartmann O, Berlin K, Eckhardt F.
• DNA-Methylation Biomarkers for Blood-Based Colorectal Cancer Screening.
  Clin. Chem., Dec 2007.
  Lofton-Day C, Model F, DeVos T, Tetzner R, Distler J, Schuster M, Song X, Lesche R, Liebenberg V, Ebert M, Molnar B, Grutzmann R, Pilarsky C, and Sledziewski A.
• Comparative DNA methylation analysis in normal and tumour tissues and in cancer cell lines using differential methylation hybridisation.
  Int J Biochem Cell Biol. 2007;39(7-8):1539-50.
  Lewin J, Plum A, Hildmann T, Rujan T, Eckhardt F, Liebenberg V, Lofton-Day C,
  Wasserkort R.
• Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
  J Urol. 2007 May;177(5):1753-8.
  Cottrell S, Jung K, Kristiansen G, Eltze E, Semjonow A, Ittmann M, Hartmann A, Stamey T, Haefliger C, Weiss G. 
• Identification and validation of colorectal neoplasia-specific methylation markers for accurate classification of disease. Mol Cancer Res. 2007 Feb;5(2):153-63. Model, F. et al.
• Control of carry-over contamination for PCR-based DNA methylation quantification using bisulfite treated DNA
  Nucleic Acids Research, doi:10.1093/nar/gkl955, Nov 28, 2006
  Reimo Tetzner et al.
• Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas.
  Gastroenterology. 2006 Nov;131(5):1418-30.
  Ebert M.P. et al.
• DNA methylation profiling of human chromosomes 6, 20 and 22.
  Nature Genetics (2006): published online 18.00 UK time, 29 October 2006; doi:10.1038/ng1909
  Eckhardt et al.
• Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia.
  Clin Gastroenterol Hepatol. 2006 Feb;4(2):212-8.
  Osborn, N.K. et al.
• DNA methylation markers - an opportunity to further individualize therapy in breast cancer?
  Personalized Medicine, November 2005, Vol. 2, No. 4, Pages 339-347
  Sabine Maier et al.
• "Molecular diagnostic applications of DNA methylation technology"
  Clinical Laboratory International, October 2005, volume 29 6, pp18-21
  Susan Cottrell
• Differential DNA methylation of gene promoters in small B-cell lymphomas.
  Am J Clin Pathol. 2005;124:430-439
  Guo J, Burger M, Nimmrich I, Maier S, Becker E, Genc B, Duff D, 
  Rahmatpanah F, Chitma-Matsiga R, Shi H, Berlin K, Huang Tim H.-M., Caldwell CW
• Identifying DNA methylation biomarkers of cancer drug response.
  Am J Pharmacogenomics. 2005;5(4):223-32
  Maier S, Dahlstroem C, Haefliger C, Plum A, Piepenbrock C
• Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers.
  Neoplasia. 2005 Aug;7(8):771-8.
  Ebert, M.P. et al.
• Methylation discriminators in NSCLC identified by a microarray based approach.
  Int J Oncol 27: 105-111, 2005. June 13, 2005
  J.K. Field, T. Liloglou, S. Warrak, M. Burger, E. Becker, K. Berlin, I. Nimmrich and S. Maier (Liverpool, UK; Berlin, Germany)
• Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.
  Cancer Res 2005; 65; (10). May 15, 2005
  John W.M. Martens et al.
• Distinction of acute lymphoblastic leukemia from acute myeloid leukemia through microarray-based DNA methylation analysis. 
  Ann Hematol. 2005 Apr;84(4):236-44. Epub 2004 Nov 6,
  Scholz C, Nimmrich I, Burger M, Becker E, Dorken B, Ludwig WD, Maier S.
• Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis.
  Carcinogenesis. 2005 Jan;26(1):37-43.
  Chen, J. et al.
• Rapid analysis of CpG methylation patterns using RNase T1 cleavage and MALDI-TOF
  Nucleic Acids Research, Online-Veröffentlichung am 2. Dezember 2004
  Abstract, Full Text
  Philipp Schatz, Dimo Dietrich and Matthias Schuster
• DNA Methylation Profiling of the Human Major Histocompatibility Complex:
  A Pilot Study for the Human Epigenome Project.  
  PLoS Biol. 2004 Nov 23;2(12):e405. 
  VK Rakyan et al.          
• Future potential of the Human Epigenome Project
  Expert Rev Mol Diagn, 2004 Sep;4(5):609-18. 
• Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates.
  Bioinformatics Advance Access, 2004, July 9 (online).
  Jörn Lewin, Armin O. Schmitt, Péter Adorján, Thomas Hildmann, Christian Piepenbrock
• Molecular diagnostic applications of DNA methylation technology.
  Clin Biochem. 2004 Jul;37(7):595-604.Review, PMID: 15234241
  Susan Cottrell et al.
• A real-time PCR assay for DNA-methylation using methylation-specific blockers.
  Nucleic Acids Research, 2004, Vol. 32, No. 1 e10
  Susan Cottrell et al.
• The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas
  Clin Cancer Res 2003 9: 4034-4042
  Hongyu Yang et al.
• Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.
  Nucleic Acids Res. 2003 May 1;31(9):e50.
  Tost J, Schatz P, Schuster M, Berlin K, Gut IG.
• Sensitive detection of DNA methylation.
  Ann N Y Acad Sci. 2003 Mar; 983:120-30. Review, PMID: 12724217
  Susan Cottrell et al.
• Oligonucleotide-based microarray for DNA methylation analysis: Principles and applications.
  J Cell Biochem 2003;88(1):138-43
  Shi H, Maier S, Nimmrich I, Yan PS, Caldwell CW, Olek A, Huang TH.
• DNA methylation markers in patients with gastrointestinal cancers. Current understanding, potential applications for disease management and development of diagnostic tools.
  Dig Dis. 2003;21(4):299-308.
  Lofton-Day, C. and R. Lesche
  Shi H, Maier S, Nimmrich I, Yan PS, Caldwell CW, Olek A, Huang TH.
• Statistical process control for large scale microarray experiments
  Bioinformatics Vol. 18 no. 90001 2002, Pages S155-S163,
  Fabian Model et al. 
• Diabetes: A Candidate Disease for Efficient DNA Methylation Profiling
  J. Nutr. 2002 132: 2440S-2443S
  Sabine Maier and Alexander Olek, Aug 2002
• Epigenomics: Genome-Wide Study of Methylation Phenomena
  Curr. Issues Mol. Biol. 4:111-128, Novik et al. 2002
• Expressed CpG Island Sequence Tag Microarray for Dual Screening of DNA Hypermethylation and Gene Silencing in Cancer Cells
  Cancer Research 62, 3214–3220, June 1, 2002
  Tim Hui-Ming Huang et al. 
• Tumour class prediction and discovery by microarray-based DNA methylation analysis
  NAR online, vol 30 n. 5,
  Adorjan et al. 2002
• Feature selection for DNA-methylation based cancer classification
  Bioinformatics vol 17,
  Model et al. 2001

Patents:

• DMH: U.S. 6,605,432.
  High throughput methods for detecting changes of DNA methylation in cancer.
  Exclusively in-licensed from University of Missouri.
• ESME-Sequencing: EP 1 369 493
  Method for the quantitative determination of the degree of methylation
  of cytosines at CpG position(s).
• Pre-analytic Workflow:
  WO 2006/039563
  Method for providing DNA fragments derived from an archived sample;
  WO 2006/113770
  Method for providing DNA fragments derived from a remote sample
• Bisulfite Treatment: WO 2001/98528
  Method for detecting cytosine methylations;
• WO 2005/038051
  Improved bisulfite conversion of DNA
• HM Amplification: WO 02/072880
  Highly sensitive method for the detection of cytosine methylation patterns
• MethyLight Real Time PCR: WO 02/072880
  Process for high throughput DNA methylation analysis Exclusively in-licensed from University of Southern California
• Carry-over Prevention: WO 2006/040187
  A method for the carry-over protection in DNA amplification systems
  targeting methylation analysis achieved by a modified pre-treatment of nucleic acids
• Bisulfite DNA Array: WO 99/28498
  Method for producing complex DNA methylation fingerprints

Posters:

• DNA Methylation Profiling in Stem Cells, Embryonic and Adult Mouse Tissue Samples using Differential Methylation Hybridization
  Rene Cortese et al.
  2nd GSA Genetic Analysis, January 2008
• Urine is the preferred remote body fluid for early identification of prostate cancer using real-time PCR detection of DNA methylation markers
  Shannon Payne et al.
  ECCO 14, September 2007
• Clinical case-control study in plasma shows that the DNA methylation biomarker, Septin 9, detects 70% of Stage I-III colorectal cancer patients
  Cathy Lofton-Day et al.
  AACR Annual Meeting, April 2007
• Identification of Novel DNA Methylation Markers Predicting Outcome in Node-Positive,
  Anthracycline-Treated Breast Cancer Patients
  Ralf Lesche et al.
  29th San Antonio Breast Cancer Symposium, December 2006
• Quantitative Genome-Wide Methylation Profiling
  Matthias Schuster et al.
  NGFN Meeting in Heidelberg, November 2006
• PITX2 is an Independent Measure of Prostate Cancer Prognosis in Radical Prostatectomy Patients.
  C. Haefliger et al.
  82nd Annual WSAUA Meeting, October 2006
• Novel Approach for the Genome-Wide Identification of Predictive DNA Methylation Marker Candidates in Cell Lines
  Tamas Rujan et al.
  AACR Special Conference in Cancer Therapeutic Development, September 2006
• Methylation analysis of the promoter region of Septin 9 – a novel biomarker for early detection of colorectal cancer.
  Xiaoling Song et al.
  AACR Special Conference in Cancer Therapeutic Development, September 2006
• Detection of Methylated DNA in Plasma from Colorectal Cancer Patients and Controls by Real-Time PCR Analysis of Septin 9
  Fabian Model et al.
  World Congress on Gastrointestinal Cancer, Juli 2006
• A Real-Time PCR Test for Septin 9 Gene Methylation Identifies Early Stage Colorectal Cancer in Plasma
  Catherine Lofton Day et al.
  AACR Annual Meeting, April 2006
• Validation of methylation markers for prostate cancer prognosis in a cohort of 605 radical prostatectomy patients
  Susan Cottrel et al.
  MD Anderson Conference, März 2006
• Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications
  Ralf Lesche et al.
  AACR Special Conference in Cancer Research, September 21-25, 2005
• An Optimised Method for Genome Wide Discovery of Differential Methylated DNA Marker on a Newly Developed CpG Island Array
  Reinhold Wasserkort et al.
  ASCO Annual Meeting, May 13-18, 2005
• DNA Methylation Biomarkers in Breast and Endometrial Cancer
  Anne Fassbender et al.
  ASCO Annual Meeting, May 13-18, 2005
• Discovery and validation of DNA methylation based markers of prostate cancer prognosis.
  Susan Cottrell et al.
  96th Annual Meeting of the AACR, April 16-20, 2005
• DNA-hypermethylation of PITX2 and risk of cancer recurrence in lymph node-negative hormone receptor-positive breast cancer patients
  John W. M. Martens et al.
  96th Annual Meeting of the AACR, April 16-20, 2005
• Epigenomics' DNA methylation based diagnostic and pharmacodiagnostic tests.
  Christoph Sachsenmaier et al.
  September 2004
• DNA methylation profiling of the human MHC: a pilot study for the human epigenome project.
  Florian Eckhardt et al.
  June 2004
• Epigenetic signature predicts failure of endocrine therapy in patients with recurrent breast cancer.
  Martens J, Nimmrich I, Koenig T, Look M, Harbeck N & Model F
  San Antonio Breast Cancer Symposium December 3-6, 2003, Abstract 313.
• Effect of MG98 Treatment on DNA Gene Promoter CpG Island Methylation Patterns in Advanced Head and Neck Carcinoma Patients
  Philip Amrein et al.
  ASCO 2003
• Methylation Profiling to Identify Colon Cancer Markers for Early Detection of Disease
  Haefliger, C. et al.
  AACR July 11-14, 2003
• Discovery of Differential Methylation using DNA microarrays
  Peter Adorjan et al.
  Biodigital 2002, October 9-11, 2002
• Chip-based DNA methylation detection in non-smallcell lung cancer
  John Kirkpatrick Field et al.
  AACR 93rd Annual Meeting, April 6-10, 2002 
• DNA methylation profiling of non-Hodgkins Lymphomas.
  James E. Woolridge et al.
  AACR 93rd Annual Meeting, April 6-10, 2002
• Genome-wide methylation profile analysis to identify colon cancer markers for early detection of disease
  Lofton-Day et. al.
  AACR meeting "Colon Cancer: Genetics to Prevention", March 2002
• The Development of Sensitive, Methylation-based, Diagnostic Marker Panels
  S. Cottrell et al.
  Gordon Research Conference, March 2002 
• Microarray-based DNA methylation profiling of paraffin-embedded tissue samples
  Antje Kluth et al.
  Late-Breaking Abstract Session of the AACR Annual meeting 2002 in San Francisco
• Tumour class prediction and discovery by microarray-based DNA methylation analysis
  Sabine Maier et al.
  AACR Conference, “Molecular Mechanisms of Gastrointestinal Cancer Development and Its Clinical Implications”, Seoul, Sep 10-14, 2001 
• Application of DNA-methylation technology for the early detection of cancer
  Cottrell, S. et al.
  International Association for the Study of Lung Cancer (IASLC), annual meeting, August 2001 
• Application of DNA Methylation Technology for the Early Detection of Cancer.
  S Cottrell et al.
  Early Detection Research Network meeting, Seattle, WA 2001 
• Tumour class prediction and discovery by microarray-based DNA methylation analysis
  Ralf Lesche et al.
  Gordon Conference: Epigenetics, Holderness School, NH, Aug 12-17, 2001
  
  The following list presents some reviews illustrating the significance of DNA-methylation for cancer:
  
• Epigenetics in cancer., Esteller M., N Engl J Med. 2008 Mar 13;358(11):1148-59. 
• DNA methylation markers: a versatile diagnostic tool for routine clinical use., Lesche R, Eckhardt F. Curr Opin Mol Ther. 2007 Jun;9(3):222-30.
• The epigenomics of cancer., Jones PA, Baylin SB. Cell. 2007 Feb 23;128(4):683-92.
• How the genome integrates intrinsic and environmental signals. Jaenisch, R, Bird A (2003) Nat Get (Suppl) 33: 245-254
• Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
  Hannes M Mueller, Martin Widschwendter. Expert Rev. Mol. Diagn. 3(4), 443-458 (2003)
• The power and the promise of DNA methylation markers
  PW Laird. Nature Rev. Cancer 3, 253-266 (2003)
• The fundamental role of epigenetic events in cancer
  Jones et al. Nature Reviews Genetics, vol. 3 (6) June 2002, pp. 415-428
• Behind the Scenes of Gene Expression
  Elizabeth Pennisi, Science Aug 10 2001: 1064-1067 
• Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
  Eric Lander, Rudolf Jaenisch
  Nature Genetics, vol 27, January 2001
• Current Topics in Microbiology and Immunology. Vol. 249: DNA Methylation and Cancer edited
  P. A. Jones, P. K. Vogt
  Springer-Verlag (2000), S. 170ff
• DNA methylation in health and disease
  Robertson KD, Wolffe AP
  Nature Reviews Genetics. 2000 October, Vol.1:11-19
• DNA methylation: past, present and future directions
  Robertson KD, Jones PA.
  Carcinogenesis. 2000 Mar;21(3):461-7. PMID: 10688866; UI: 20156136
• DNA methylation
  Singal R, Ginder GD.
  Blood. 1999 Jun 15;93(12):4059-70. PMID: 10361102; UI: 99290759
• Cancer epigenetics comes of age
  Jones PA, Laird PW.
  Nat Genet. 1999 Feb;21(2):163-7.PMID: 9988266; UI: 99140765